Type of HIV Influence on Iron Metabolism in Pregnant and Non-pregnant Women on Antiretroviral Therapy in Integrated Centre for Bioclinical Research of Abidjan (Côte d'Ivoire)

Main Article Content

Soualio Kamagate
Mathieu Nahounou Bleyere
Baudouin Angoua Kokore
Jean-baptiste N’Guessan Oussou
Paul Angoué Yapo

Abstract

Introduction: HIV has a significant effect on iron metabolism in women of childbearing age in developing countries. The purpose of this study is to identify in this population layer, the type of HIV truly responsible for changes in iron metabolism.

Materials and Methods: Thus, 395 HIV infected women of childbearing age were selected. This population included 120 non-pregnant women and 275 pregnant women in consultation at the Integrated Center for Bioclinical Research Abidjan (ICBRA). Blood samples were collected from each of the subjects for HIV status, hematological, immunological, and various biological indicators of iron status determination.

Results: The results of the study indicated that women infected with HIV-1 and HIV-2 had a high mean values ​​of hemoglobin, serum ferritin and iron stores. In addition, women infected with the two types of HIV had the lowest mean values ​​of total transferrin binding capacity, transferrin saturation factors, and CD4+ levels compared to the other groups of women. However, women infected with HiV-1 showed the highest prevalence of anemia (65.3%). This rate of anemia is higher in pregnant women (45.3%) compared to non-pregnant one (20%). Moreover, 77.5% of women infected with HIV had abnormal iron status with a high prevalence of inflammatory anemia (52.9%). No significant nutritional anemia was observed in the study population.

Conclusion: Pregnant women were the most affected by the degradation of iron metabolism. HIV-1 was the type of virus that caused the most impairment of iron status in the subjects of our study.

Keywords:
Iron metabolism, HIV, inflammatory anemia, woman of childbearing age, abidjan

Article Details

How to Cite
Kamagate, S., Bleyere, M. N., Kokore, B. A., Oussou, J.- baptiste N., & Yapo, P. A. (2019). Type of HIV Influence on Iron Metabolism in Pregnant and Non-pregnant Women on Antiretroviral Therapy in Integrated Centre for Bioclinical Research of Abidjan (Côte d’Ivoire). Asian Hematology Research Journal, 2(1), 1-15. Retrieved from http://journalahrj.com/index.php/AHRJ/article/view/30098
Section
Original Research Article

References

Dallman PR. Iron deficiency in the Weanling: a nutritional problem on the way to resolution. Acta Paediatr Scandinavica. 1986;323:59-67.

Dallman PR. Iron deficiency and the immune response. Am J of Clin Nutr. 1987; 46:329-314.

Cook M. Adaptation in iron metabolism. The Am J of Clin Nutr. 1990;5(1):301-25.

UNICEF/UNU/WHO Déclaration conjointe de l’Organisation Mondiale de la Santé et du Fonds des Nations Unies pour l’Enfance: Focaliser sur l’anémie; vers une approche intégrée pour un contrôle efficace de l’anémie ; 2005.

Available:http:/www.who.org/publications/index.html

(Accessed: 5 april 2012)

Vanderjagt DJ, Brock HS, Melah GS, El-Nafaty AU, Crossey MJ, Glew RH. Nutritional factors associated with anaemia in pregnant women in northern Nigeria. J of Health Pop and Nutr. 2007;25:75-81.

Wajcman H, Lantz B, Girot R. Les maladies du globule rouge. Paris, INSERM. Méd-Sci. 1992;81-456.

Antelman G, Msamanga GI, Spiegelman D, Ernest JNU, Narh R, Hunter DJ, Fawzi WW. Nutritional factors and infectious disease contribute to anemia among pregnant women with human immunodeficiency virus in Tanzania. The J of Nutr. 2000;130:1950–1957.

Baum MK, Shor-Posner G, Lu Y, Rosner B, Sauberlich HE, Fletcher MA, Szapocznik J, Eisdorfer C, Buring JE, Hennekens CH. Micronutrients and HIV-1 disease progression. AIDS. 1995;9: 1051-1056.

UN-AIDS-UNAIDS Côte d'Ivoire in. Côte d’Ivoire ; 2017.

Available:www.unaids.org/fr/regionscountries/ctedivoire consulted the 06/08/2016

Montagnier L. SIDA et infection par le VIH. Paris : Flammarion. 1998;63.

Kamagate S, Bléyéré MN, Koné M, Kouakou LK, Doumatey S, Amonkan AK, Sawadogo D, Ehilé EE, Chenal H, Yapo PA. Iron metabolism andantiretroviral therapy (ART) in women with HIV in Abidjan (Côte d’Ivoire). Int J of Biomol and Biomed. 2012a;2(2):1-12.

Kamagaté S, Bléyéré MN, Kouakou LK, Koné M, Doumatey S, Amonkan AK, Konan AB, Sawadogo D, Chenal H, Ehilé EE, Yapo PA. Alteration of iron stores in women of reproductive age with HIV in Abidjan (Côte d’Ivoire). Int J of Biosci. 2012b;2(7):11-22.

Bléyéré MN, Kamagate S, Kouakou LK, Doumatey S, Sawadogo D, Yapo PA. Heterogeneity of iron status and antiretroviral therapy during pregnancy in Côte d’Ivoire. J of Phys and Pharm Adv. 2013a;3(3):66-84.

Bléyéré MN, Kagamate S, Kouakou LK, Doumatey S, Sawadogo D, Yapo PA. Pregnancy, HIV and antiretroviral therapy on iron metabolism in Côte d’Ivoire. International J of Clin Nutr. 2013b;1(1):1-10.

Bléyéré MN, Kamagate S, Amonkan AK, Doumatey S, Yapo PA. Interaction of HIV and pregnancy on iron metabolism in Côte d'Ivoire. Austr J of Basic and Appl Sci. 2013c;7(4):143-153.

Barin F, Plantier JC, Brand D. Human immunodeficiency virus serotyping on dried serum spots as a screening tool for the surveillance of the AIDS epidemic. J of Med Virol. 2006;78:S13-S18.

Drylewicz JSM, Lazaro E, Damond F, Bonnet F, Simon F, Dabis F, Brun-Vezinet F. Geneviève Chêne and Rodolphe Thiebaut. Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France. AIDS. 2008;22:457-468.

Wagner. Le rôle du laboratoire dans l'exploration du métabolisme du fer. Revue de l'ACOMEN. 2000;6:23-27.

Vernet–Nyssen M. Recent findings concerning serum iron, the iron binding capacity of serum, and transferrin saturation suggested terminology. Ann Biol Clin-Paris. 1981;39(5):301-7.

Nathalie M, Pascal P. Quels marqueurs pour le bilan martial ? Spectra Biol. 2007;163:48-53.

Vernet M, Corberand J, David V, Deugnier Y, Frey J, Giraudet P, Renversez JC, Sebahoun G. Algorithmes de prescription recommandés pour le diagnostic d’un déficit et d’une surcharge en fer. Ann de Biol Clin (Paris). 2001;59:149-155.

UNICEF/UNU/WHO). Iron deficiency anemia: Assessment, prevention and control. WHO reference number: WHO/NHD/01.3 ; 2001.

Available:https://www.who.int/nutrition/publications/.../anaemia_iron_deficiency/...NHD_01.3/e..consulted the 12/09/2016.

Société de Nutrition et de Diététique de Langue Française (SNDLF). Anémies nutritionnelles. Cahier de Nutr et de Diét. 2001;36(Hors-série):76-81.

Statsoft. Statistica (Data analysis software system). 2005;7(1).

Available:www. Statsoft.com

Ihaka R, Gentleman RR: A language for data analysis and graphics. J of Comput and Graphic Statist. 1996;5:299-314.

David TS, et Groopman JE, Hématologie, Oncologie du Sida. In: Cecil. Traité de Médecine Interne. Paris: Flammarion. 1997;1870-4.

Diallo DA, Baby M, Dembele M, Keita A, Sidibe A, Cisse IAH, Diop CT, Maïga II, Traore AK, Traore HA. Fréquence, facteurs de risque et valeur pronostique de l’anémie associée au VIH/sida chez l’adulte au Mali. Bull Soc de Pathol Exot. 2003;96(2):123-127.

Thankachan P, Kalasuramath S, Hill AL, Thomas T, Bhat K, Kurpad AVA. Mathematical model for the hemoglobin response to iron intake, based on iron absorption measurements from habitually consumed Indian meals. Eur J of Clin Nutr; 2011.

DOI:10.1038/ejcn 169.

Sinha G, Choi TJ, Nayak U, Gupta A, Nair S, Gupte N, Bulakh PM, Sastry J, Deshmukh SD, Khandekar MM, Kulkarni V, Bhosale RA, Bharucha KE, Phadke MA, Kshirsagar AS, Bollinger RC. Clinically significant anemia in HIV-infected pregnant women in India is not a major barrier to zidovudine use for prevention of maternal-to-child transmission. J of Acquir Immune Defic Syndr. 2007;1;45(2):210-217.

Obirikorang C, Yeboah FA. Blood haemoglobin measurement as a predictive indicator for the progression of HIV/AIDS in resource-limited setting. J of Biomed Sci. 2009;16:102.

Kamagate S, Bléyéré MN, Ouattara H, Toni TD, Yapo PA. Blood biological parameters of population living with HIV/AIDS on antiretroviral therapy in integrated centre for bioclinical research of Abidjan (Côte d'Ivoire). Haya: The Saudi Journal of Life Sci. 2016;1(4):130-140.

Katodritou E, Christakis J. Recent advances in the pathogenesis and management of anaemia of chronic disease. Haematol. 2006;9(1):45-55.

Handelman GJ, Levin NW. Iron and anemia in human biology: A review of mechanisms. Heart Failure Reviews. 2008; 13(4):393-404.

Semba RD, Shah N, Strathdee SA, et Vlahov D. High prevalence of iron deficiency and anemia among female injection drug users with and without HIV infection. J of Acquir Immune Defic Syndr. 2002;29:142–144.

Sullivan PS, Hanson DL, Chu SY, Jones JL, Ward JW. Epidemiology of anemia in Human Immunodeficiency Virus (HIV)-infected persons: Result from the multistate adult and adolescent spectrum of HIV disease surveillance project. Blood. 1998;91:301-308.

Bléyéré MN, Joulia-Ekaza D, Yapo AP, Yao JD, N’guessan BB, A. Cathy MN, Vanga M, Kone M, et Ehile EE. Hétérogénéité du statut en fer chez la femme au cours de la grossesse en Côte-d’Ivoire. Ann Biol Clin. 2007;65(5):525-532.

Obirikorang C, Yeboah FA. Blood haemoglobin measurement as a predictive indicator for the progression of HIV/AIDS in resource-limited setting. J of Biomed Sci. 2009;16:102.

Johannessen A, Naman E, Gundersen SG, et Bruun JN. Antiretroviral treatment reverses HIV-associated anemia in rural Tanzania. BMC Infect Diseases. 2011;11: 190. Available:http://www.biomedcentral.com/1471-2334/11/190

Oladeinde BH, Phil RM, Olley M, Anunibe JA. Prevalence of HIV and anemia among pregnant women. North Am j of med and Sci. 2011;3:548-351.