Determination of Some Haemotological Parameters in Children Infected with Plasmodium falciparum in Murtala Muhammad Specialist Hospital, Kano State, Nigeria

Main Article Content

I. Abdulmumin
E. O. Osime
M. Abdullahi
I. M. Zubair

Abstract

Aim: The aim of the study is to determination of Some Haemotological Parameters in children infected with Plasmodium falciparum in Murtala Muhammad Specialist Hospital, Kano, Kano State, North Western Nigeria.

Study Design: The study is analytic study.

Place and Duration of the Study: In this research of the 350 children between the aged groups of 1-10 years infected with Plasmodium falciparum attending Murtala Muhammad Specialist Hospital Kano State were used for the study.

Methodology: Malaria Rapid diagnostic kids (RDTs) kits were used for qualitative immunochromatographic flow tests in a dipstick (strip) or cassette forms that detect malaria antigen present in peripheral blood. Haemoglobin, Packed Cell Volume (PCV) and Reticulocytes count were determined using standard procedure.

Results: A total of 350 subjects with Plasmodium falciparum, 190 (54.3%) male and 160 (45.7%) female with 100 control subjects both male and female were recruited in this study aged from 1 – 10 years. Relative distribution of 212(60.6%) and 138(53.8%) of the subjects were anaemic based on PCV and haemoglobin values respectively. It was also observed that 216(61.8%) with high reticulocytes and 134(38.2%) with normal value, while 0(0%) have lower value. However, the comparative mean value and standard deviation of female PCV, haemoglobin of Plasmodium falciparum patients and control were significantly reduced (P>0.05), while reticulocytes of Plasmodium falciparum patients and control were significantly high (P<0.05).

Conclusion: In conclusion, the result indicated low PCV and haemoglobin among of male and female infected with Plasmodium falciparum because were significantly reduced (P>0.05) in patients and control, while reticulocytes of Plasmodium falciparum patients and control were significantly high (P<0.05).

Keywords:
Children, haemoglobin, Plasmodium falciparum, packed cell volume reticulocytes.

Article Details

How to Cite
Abdulmumin, I., O. Osime, E., Abdullahi, M., & M. Zubair, I. (2020). Determination of Some Haemotological Parameters in Children Infected with Plasmodium falciparum in Murtala Muhammad Specialist Hospital, Kano State, Nigeria. Asian Hematology Research Journal, 2(4), 1-8. Retrieved from http://journalahrj.com/index.php/AHRJ/article/view/30115
Section
Original Research Article

References

Rich SM, Leendertz FH, Xu G, Lebreton M, Djoko, et al. The origin of malignant malaria. Proceedings of the National Academy of Sciences. 2009;106(35):14902–14907.

Kepha S, Nikolay B, Nuwaha F, Mwandawiro CS, Nankabirwa J, et al. Plasmodium falciparum parasitaemia and clinical malaria among school children living in a high transmission setting in western Kenya. Malaria Journal. 2016;15:157.

WHO. Achieving the malaria MDG target: Reversing the incidence of malaria 2000–2015. Geneva. World Health Organization and the United Nations Children’s Fund; 2015.

Nmadu PM, Peter E, Alexander P, Koggie AZ, Maikenti JI. The prevalence of malaria in children between the ages 2-15 visiting Gwarinpa General Hospital Life-Camp, Abuja, Nigeria. Journal of Health Science. 2015;5:47–51.

Onyiri N. Estimating malaria burden in Nigeria: A geo-statistical modelling approach. Geospat Health. 2015;10:306.

Joy D, Feng X, Mu J, Furuya T, Chotivanich K, et al. Early origin and recent expansion of Plasmodium falciparum. Science. 2003;300(5617):318–321.

Nmadu PM, Peter E, Alexander P, Koggie AZ, Maikenti JI. The prevalence of malaria in children between the ages 2-15 visiting Gwarinpa General Hospital Life-Camp, Abuja, Nigeria. Journal of Health Science. 2015;5:47–51.

Kepha S, Nikolay B, Nuwaha F, Mwandawiro CS, Nankabirwa J, et al. Plasmodium falciparum parasitaemia and clinical malaria among school children living in a high transmission setting in Western Kenya. Malaria Journal. 2016;15: 157.

Cheesbrough Monica. District laboratory practice in tropical countries. Second Edition Cambridge University Press. 2006;2:340–347.

Rayner J, Liu WM, Peeters M, Sharp PM, Hahn BH. A plethora of Plasmodium species in wild apes: A source of human infection. Trends in Parasitology. 2011;467(5):222–229.

Carmel R. Anaemia and aging: an overview of clinical, diagnostic and biological issue. Blood. 2001;15:9–18.

Gobir Z, Tukur Z. Prevalence of malaria parasitemia using rapid diagnostic test among apparently healthy children Kano, Nigeria. Journal of Medicine in the Tropics. 2014;16:1–4.

Adrian JFL, Sebastian U, Bertrand L, Leopold L, Ruprecht S, et al. Antibody responses to plasmodium falciparum: Evolution according to the severity of a prior clinical episode and association with subsequent reinfection. American Journal Tropical Medicine Hygiene. 2000;62(5): 566–572.

Rich SM, Leendertz FH, Xu G, Lebreton M, Djoko CF, et al. The origin of malignant malaria. Proceedings of the National Academy of Sciences. 2009;106(35): 14902–14907.

Agravat AH, Dhruva GA. Hematological changes in patients of malaria. Journal of Cell and Tissue Research. 2010;10(3): 2325-2329.

Paul RE, Diallo M, Bre PT. Mosquitoes and transmission of malaria parasites not just vectors. Malaria Journal. 2004;3:39.

Stadlmann J, Pabst M, Kolarich D, Kunert R, Altmann F. Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides. Proteomics. 2008;8(14):2858–2871.

Hardison RC. Evolution of haemoglobin and its genes. Cold Spring Harbor Per-spectives in Medicine. 2012;2(12):116-127.

Babacar M, Birahim N, Bacary D, Adama T, Olivier G, et al. The use of crude Plasmodium falciparum antigens for comparison of antibody responses in patients with mild malaria vs. cerebral malaria. Iranian Journal of Immunology. 2010;7(3):150-161.

Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, et al. Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). Proceedings of the National Academy of Science of the Unite State of America. 2010;107(46):19985–19990.