Asian Hematology Research Journal

Background: High malaria burden   has led to the increase use of insecticides in the tropics and subtropics. This study thus aimed at assessing the effect of insecticides inhalation on coagulation profile using experimental animal model.

Methods: Sixteen adult male rabbits divided into four groups A, B, C and D. Group A, B and C were exposed to 20 ml of pyrethroid insecticides containing 0.05% pralletrin and 0.15% cyfluthrin by inhalation for 10 mins, 20 mins, and 30mins respectively. Group D served as the control and was not exposed. Baseline study was done on all the animals before grouping for exposure. The pyrethroid insecticides was soaked in cotton wool (2.5g) in a container that was able to prevent the animal from ingesting it, which was placed inside  the room A, B and C for 10 mins, 20 mins and 30 mins respectively. The rabbits were exposed for three weeks and samples were collected at the end of each week. Exposure was discontinued after day 21 and Samples were collected again on day 28 and 35 respectively which is the fourth and fifth week. All the animals were monitored twice daily for clinical signs like jerky movement, skin scratching, licking of legs and other body parts.

Results: Data analysis revealed that there was significant effect of inhalation of insecticides on coagulation profile of rabbits at 10 min, 20 mins and 30 mins of exposure. There was significant decreased in PTTK and INR values. But, there was no significant effect on prothrombin time.

Conclusion: The results from this study have shown that aerosol of these pyrethroid insecticides (pralletrin and cyfluthrin) has effect on coagulation parameters. It is thus recommended that one should avoid exposure to the aerosol of these insecticides during domestic, veterinary,agricultural or industrial use.