Asian Hematology Research Journal

Long-term Outcome of Splenectomy in Immune Thrombocytopenia (ITP)

Tarun Kumar Dutta *

Medicine and Clinical Hematology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

*Author to whom correspondence should be addressed.

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Abstract

ITP is a chronic illness with frequent mucosal bleeding. Though the first line treatment is corticosteroids, relapse is frequent which necessitates splenectomy. Response to splenectomy is usually good initially; however, over the years relapses are frequent.  Drugs then used are azathioprine, mycophenolate mofetil, anti-D globulin, TPO-receptor agonists, rituximab, cyclosporine, etc. Ultimately there is a small subset of patients who may require a small dose of prednisolone lifelong.

Keywords: Splenectomy, mycophenolate mofetil, rituximab, cyclosporine

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