Asian Hematology Research Journal

  • About
    • About the Journal
    • Submissions & Author Guideline
    • Editorial Policy
    • Accepted Papers
    • Editorial Board Members
    • Reviewers
    • Printed Hard copy
    • Subscription
    • Membership
    • Publication Ethics and Malpractice Statement
    • Digital Archiving
    • Contact
  • Archives
  • Indexing
  • Publication Charge
  • Submission
  • Testimonials
  • Announcements
Advanced Search
  1. Home
  2. Archives
  3. 2018 - Volume 1 [Issue 4]
  4. Original Research Article

Submit Manuscript


Subscription



  • Home Page
  • Author Guidelines
  • Editorial Board Member
  • Editorial Policy
  • Propose a Special Issue
  • Membership

Evaluation of the Diagnostic Value of Ret-He among Sickle Cell Disease Children with Iron Deficiency Anaemia on Haematinics

  • David Ntiamoah Ofosu
  • Clement Opoku-Okrah
  • Victoria Bam
  • Selorm Philip Segbefia

Asian Hematology Research Journal, Page 1-7

Published: 12 March 2019

  • View Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract


Introduction: The determination of the amount of hemoglobin in reticulocytes provides a more real-time assessment of the iron status of the bone marrow. Ret-He, the iron molecule found in reticulocytes, unlike most biochemical markers is not affected by inflammation. Hence its determination provides a better way of detecting the presence or absence of iron for erythropoiesis.


Objectives: The aim of the study was to evaluate the diagnostic value of Ret-He and to compare it with serum ferritin and Red Blood Cell (RBC) indices: haemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH) and Red Cell Distribution Width (RDW) in detecting iron deficiency among Sickle Cell Disease (SCD) children.


Materials and Methods: 89 SCD children attending KATH sickle cell clinic were enrolled in the study. Complete Blood Count (CBC), Reticulocyte haemoglobin content (Ret-He) and biochemical tests [ferritin and C - reactive protein (CRP)] were performed from venous blood samples. Iron deficiency anaemia (IDA) was diagnosed when subject’s Hb, MCV, MCH, RDW, serum ferritin and Ret-He were below cut-off values.


Results: Receiver Operating Characteristic (ROC) analysis showed the following results: RBC indices (AUC=0.953, sensitivity=90.7%, specificity=100%, p <0.05), Ret-He (AUC=0.647, sensitivity=34.9%, specificity=94.4%, p > 0.05) and serum ferritin (AUC=0.476, sensitivity=90.2%, specificity=11.1%, p > 0.05). 


Conclusion: The findings of this study suggest that the red cell indices is the most accurate, sensitive and specific among the three diagnostics tools used in this study to detect IDA in SCD children on hematinics.


Keywords:
  • Sickle cell disease
  • ferritin
  • iron-deficiency
  • red blood cell indices
  • reticulocytes
  • anaemia
  • Full Article - PDF
  • Review History

How to Cite

Ofosu, D., Opoku-Okrah, C., Bam, V., & Segbefia, S. (2019). Evaluation of the Diagnostic Value of Ret-He among Sickle Cell Disease Children with Iron Deficiency Anaemia on Haematinics. Asian Hematology Research Journal, 1(4), 1-7. Retrieved from https://journalahrj.com/index.php/AHRJ/article/view/30095
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Abstract View: 2658 times
    PDF Download: 1171 times

Download Statistics

Downloads

Download data is not yet available.
  • Linkedin
  • Twitter
  • Facebook
  • WhatsApp
  • Telegram
Make a Submission / Login
Information
  • For Readers
  • For Authors
  • For Librarians
Current Issue
  • Atom logo
  • RSS2 logo
  • RSS1 logo


© Copyright 2010-Till Date, Asian Hematology Research Journal. All rights reserved.