Knowledge of Haemoglobin Types at Union among Couples and Impact on Offspring; a Cross-sectional Study in Southern Nigeria
Asian Hematology Research Journal,
Aims: This study aimed at assessing haemoglobin (Hb) types of couples, their knowledge of Hb types at the time of union and outcome on offspring.
Study Design: Cross-sectional descriptive study.
Place and Duration of Study: This study was carried out in Abi local government area of Cross River State between March and July, 2018.
Methodology: Two hundred consenting couples and their 445 offspring were enrolled in this study. A pre-tested structured questionnaire was administered by two trained interviewers to capture the bio-data and other pertinent information in relation to couple’s knowledge of Hb types. Blood sample was collected from each participant and Hb type was determined by electrophoresis in alkaline pH using cellulose acetate method.
Results: Thirty-eight percentage (38%) of the females and 30% of the males who participated in this study lacked knowledge of their haemoglobin type at the time of producing offspring. Haemoglobin type AA predominated (70% of females and 72% of males), while 30% females and 28% males accounted for the presence of AS. The Hb types of their offspring were 79% AA, 15% AS and 6% SS. Among AS and AS couples, 67% had no knowledge of their Hb type prior to having children and contributed to 85% of children with Hb SS.
Conclusion: Ignorance of haemoglobin types prior to having children contributed to the high prevalence of Hb SS observed in the present study.
- Haemoglobin types
- sickle cell disease
How to Cite
McGann PT. Sickle cell anemia: An underappreciated and unaddressed contributor to global childhood mortality. J Pediatr. 2014;165(1):18–22.
Hamideh D, Alvarez O. Sickle cell disease related mortality in the United States (1999–2009) Pediatr Blood Cancer. 2013; 60(9):1482–6.
Lobo CL, do Nascimento EM, de Jesus LJ, de Freitas TG, Lugon JR, Ballas SK. Mortality in children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. Hematol., Transfus. Cell Ther. 2018;40(1):37-42.
Wastnedge E, Waters D, Patel S, Morrison K, Goh MY, Adeloye D, et al. The global burden of sickle cell disease in children under five years of age: A systematic review and meta-analysis. Journal of Global Health. 2018;8:021103.
Rahimy MC, Gangbo A, Ahouignan G, Adjou R, Deguenon C, Goussanou S, et al. Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anaemia in sub-Saharan Africa setting. Blood. 2003; 102(3):834-8.
Ohene-Frempong K, Oduro J, Tetteh H, Nkrumah F. Screening newborns for sickle cell disease in Ghana. Pediatrics. 2008; 121:(Issue Supplement 2).
Tshilolo L, Kafando E, Sawadogo M, Cotton F, Vertongen F, Ferster A, et al. Neonatal screening and clinical care programmes for sickle cell disorders in sub-Saharan Africa: Lessons from pilot studies. Public Health. 2008;122(9): 933-41.
Sadarangani M, Makani JKAN, Ajala-Agbo T, Newton CR, Marsh K, Williams TN. An observational study of children with sickle cell disease in Kalifi Kenya. British Journal of Haematology. 2009; 146(6):675-82.
Rwezaula S, Cox S, Lowe B, Magesa, P, Massawe A, Newton C, et al. Neonatal screening for haemoglobinopathies at Muhimbili National Hospital, Dar es Salaam. A pilot study. British Journal of Haematology. 2011;153:27.
Williams H, Silva S, Simmons LA, Tanabe P. A telephonic mindfulness-based intervention for persons with sickle cell disease: study protocol for a raandomized controlled trial. Trials. 2017; 18(1):218.
Abioye-Kuteyi EA, Oyegbade O, Bello I, Osakwe C. Sickle cell knowledge, premarital screening and marital decisions among local government workers in Ile-Ife, Nigeria. Afr J Prim Health Care Fam Med. 2009;1(1):022.
Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K. Sickle cell disease: New opportunities and challenges in Africa. The Scientific World Journal; 2013. Article ID 193252.
Akodu SO, Disu EA, Njokanma OF. Pattern and factors associated with hemoglobin genotype testing among children attending a University Teaching Hospital in Lagos, Nigeria. The Nigerian Journal of General Practice. 2015;13(1): 16-20.
Mulumba LL, Wilson L. sickle cell disease among children in Africa: An integrative literature review and global recommendations. International Journal of Africa Nursing Sciences. 2015;3:56-64.
Odunvbun ME, Okolo AA, Rahimy CM. Newborn screening for sickle cell disease in a Nigerian hospital. Public Health. 2008; 122(10):1111-6.
Aneke JC, Okocha CE. Sickle cell disease genetic counselling and testing: A review. Archives of Medicine & Health Sciences. 2016;4:50-7.
Akhigbe RE, Ige SF, Afolabi AO, Azeez OM, Adegunlola GJ, Bamidele JO. Prevalence of haemoglobin variants, ABO and rhesus blood groups in Ladoke Akintola University of Technology, Ogbomoso, Nigeria. Trends in Medical Research. 2009;4(2):24-9.
Umoh AV, Abah GM, Ekanem TI, Essien EM. Haemoglobin genotypes: A prevalence study and implications for reproductive health in Uyo, Nigeria. Nigerian Journal of Medicine. 2010;19(1): 36-41.
Akwiwu EC, Usanga EA, Akpotuzor JO. Comparative study of haemoglobin types in coastal (Yenogoa) and hinterland (Owerri) communities in South-Eastern Nigeria. Journal of Medical Laboratory Science. 2011;20(2):16-20.
Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Dewi M, et al. Global epidemiology of sickle haemoglobin in neonates: A contemporary geostatistical model-based map and population estimates. Lancet. 2013;381:142-51.
Ware RE. Is sickle cell anemia a neglected tropical disease? PLoS Neglected Tropical Diseases. 2013;7:e2120.
Luzatto L. Sickle cell anaemia and malaria. Mediterranean Journal of Hematology and Infectious Diseases. 2012;4:e2012065.
Bunn HF. The triumph of good over evil: Protection by the sickle gene against malaria. Blood. 2013;121(1):20-5.
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