P1 Blood Group Antigen Dominant among Indigenes of Ogoni Ethnicity in Rivers State of Nigeria

Main Article Content

Serekara Gideon Christian
Evelyn Mgbeoma Eze
Ibioku Elekima


Aim: The study aimed to determine the percentage distribution and frequency of occurrence of P1 blood group antigen among indigenes of Ogoni ethnicity in Rivers State of Nigeria.

Study Design: The study was a cross-sectional study conducted on Ogoni indigenes whose first generational parental origin is Ogoni. It consisted of one hundred and one apparently healthy subjects (fifty-two males and forty-nine females) within the age bracket of 30–60 years; free from transfusion transmissible infections after confirmation by serological testing.

Place and Duration of Study: Ogoniland is located along the Niger Delta Easten edge and to the North-East of Port Harcourt. All subjects were enrolled on the same day and their blood sample collected, transported and stored in cold chain (2 to 8°C) before the analysis which was carried out within 24 hours.

Methodology: The presence of the P1 blood group was identified using Anti-P1 monoclonal reagent, with method described and reagent prepared by Lorne Laboratories Ltd, UK.

Results: The study revealed the percentage distribution of the P1 blood group to be 81.18% in the total population with a frequency occurrence of 82.

Conclusion: The P1 blood group is dominant amongst the Ogonis, though not implicated in haemolytic transfusion reaction and haemolytic disease of the newborn, it can be associated with diseases caused by Escherichia coli. Therefore, it is necessary to put into consideration that indigenes of Ogonis with P1 blood group may likely be prone to Escherichia coli infections as a result of the presence of P1 antigen.

P1 blood group, antigen, Indigenes of Ogoni, Rivers State, Nigeria.

Article Details

How to Cite
Christian, S. G., Eze, E. M., & Elekima, I. (2020). P1 Blood Group Antigen Dominant among Indigenes of Ogoni Ethnicity in Rivers State of Nigeria. Asian Hematology Research Journal, 3(1), 30-35. Retrieved from https://journalahrj.com/index.php/AHRJ/article/view/30125
Original Research Article


Denomme GA. Molecular basis of blood group expression. Transfusion and Apheresis Science. 2011;44:53–63.

Lorne Laboratories. Monoclonal blood grouping reagents: Anti-P1 monoclonal. Document Reference Number: CEPI315. United Kingdom: Lorne Laboratories Ltd; 2018.

Reid ME, Calhoun L, Petz LO. Erythrocyte antigen and antibodies. In Lichtman MA, Beutler E, Kipps, TJ, Seligsohn U, Kaushansky K, Prchal JT, (Eds). Williams Haematology, 7th Edition, (pp 2119), New York: McGraw-Hill; 2006.

Reid ME, Lomas-Francis C, Olsson ML. The Blood Group Antigen Factsbook, 3rd Edition, Amsterdam: Academic Press (Elsevier); 2012.

Reid ME, Lomas-Francis C. Blood Group Antigen Fact Book, 2nd Edition, San Francisco: Academic; 2003.

Issitt PD, Anstee DJ. Applied Blood Group Serology, 4th Edition, Durham: Montgomery Scientific; 1998.

Thuresson B, Westman JS, Olsson ML. Identification of a novel A4GALT exon reveals the genetic basis of the P1/P2 histo-blood groups. Blood. 2011;117:678–687.

Downs T. Other Blood Group System. In: Quinley ED. (Eds) Immunohematology Principles and Practice, 3rd Edition, (pp 119-134), Philadelphia: Lippincott Williams & Wilkins; 2011.

Iwamura K, Furukawa K, Uchikawa M. The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. Journal of Biological Chemistry. 2003;278(45): 44429–44438.

Brown KE, Hibbs JR, Gallinella G, et al. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). N. Engl J. Med. 1994;330:1192-1196.

Young NS, Brown KE. Parvovirus B19. N Engl J. Med. 2004;350:586-597.

Moulds JM, Moulds JJ. Blood group associations with parasites, bacteria and viruses. Transfus Med Rev. 2000;14: 302.

Ziegler T, Jacobsohn N, Funfstuck R. Correlation between blood group phenotype and virulence properties of Escherichia coli in patients with chronic urinary tract infection. Int J. Antimicrob Agents. 2004;24(Suppl 1):70-75.

Smart E, Amstrong B. Blood group systems. ISBT Science Series. 2008;3:68–92.

Oyinlade OA, Vincent JM. The Ogoni of Nigeria. Anthropology Faculty Publications. 2020;113.

ENCYCLOpedia.com. Ogoni.
Available:https://www.encyclopedia.com (Accessed: October 10, 2019)

Cheesbrough M. District laboratory practice in tropical countries, 2nd Edition, Part 2. Cambridge: Cambridge University Press; 2010.

Heiken A, Balogun RA, Swan A, Rasmuson M. Population genetic studies in Nigeria. Hereditas. 1974;76:117-136.

Blumberg BS, Ikin EW, Mouranta E. The blood groups of the pastoral Fulani of Northern Nigeria and the Yoruba of Western Nigeria. Am. J. Phys. Anthropol. 1961;19:195-201.

Motswaledi MS, Kasvosve I, Oguntibeju OO. Blood group antigens C, Lub and P1 may have a role in HIV infection in Africans. PLoS ONE. 2016;11(2): e0149883.
DOI: 10.1371/journal.pone.0149883