Biclonal B-Chronic Lymphocytic Leukemia: A rare Case Report with Review of Literature
Asian Hematology Research Journal,
Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia is a neoplasm composed of monomorphic small mature B cells that co-express CD5, CD23 and one type of immunoglobulin light chain either kappa or lambda, which is necessary for the diagnosis. Here, we report a case in a 65 year woman with morphological diagnosis of B-Chronic Lymphocytic Leukemia. On flowcytometry analysis, immunoglobulin light chain restriction was not apparent as B cells expressed both kappa & lambda light chains without a clear monotypic population. Sequential gating on flowcytometry revealed two monoclonal B-cell populations and helped in identification of this rare case of biclonal disease in chronic lymphocytic leukemia (CLL).
- bone marrow
How to Cite
Swerdlow S, Campo E, Harris N, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008.
Sánchez ML, Almeida J, Gonzalez D, Gonzalez M, Balanzategui A, Garcia-Marcos MA, et al. Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone. Blood. 2003;102(8):2994-3002.
Ghodke KA, Patkar NV, Subramanian PG, Gujral S, Kadam PA et al. Biclonal chronic lymphocytic leukemia: A study of two cases and review of literature. IJPM. 2017; 60(1):84-86.
Campos GJ, Ríos Herranz E, De Blas Orlando JM, Martín Noya A, Parody – Ruiz Berdejo R, Rodríguez Fernández JM. Chronic lymphocytic leukemia with two cellular populations: A biphenotypic or biclonal disease. Ann Hematol. 1997;74 (5):243 6.
Kern W, Bacher U, Schnittger S, Dicker F, Alpermann T, Haferlach T, et al. Flow cytometric identification of 76 patients with biclonal disease among 5523 patients with chronic lymphocytic leukaemia (B‑CLL) and its genetic characterization. Br J Haematol. 2014;164(4):565‑9.
Abstract View: 35 times
PDF Download: 59 times