Hematological Profiles of Naturally Infected Pigs Treated with Bridelia ferruginea Leaf Extracts
Asian Hematology Research Journal,
Page 1-10
Abstract
Bridelia ferruginea (Benth) Phyllanthaceae called “Kizni” in Hausa, “Iralodan” in Yoruba and “Ola” in Igbo languages are widely used as food and as medicines in traditional medical practice. They are widely found in the Savannah regions especially in the moister regions. This study explores the hematological profiles of pigs naturally infected with gastrointestinal nematodes treated with N-hexane leaf extract of Bridelia ferruginea in three divided doses (125 mg/kg, 250 mg/kg and 500 mg/kg body weight) for twelve days. The hematological assay was carried out using mind Ray hematology auto analyzer (BC 5300). Results showed that leaf extract of B. ferruginea exhibited significant increase (p<0.05) in packed cell volume, total leukocyte, hemoglobin, neutrophil, lymphocyte, monocyte and eosinophil counts. However, no significant difference (p<0.05) was observed on the total erythrocyte and platellet counts of the animals. The results in our findings demonstrated that the leaf extract of B. ferruginea is capable of stimulating blood cell formation and act as active phagocytic agent against foreign compounds, and therefore can be used to formulate new plant-based phyto-medicine in a bid to improve human and animal health.
Keywords:
- Hematology
- Bridelia ferruginea
- pigs
- gastro-intestinal nematodes
- infections.
How to Cite
Oladejo, A. A., & Osukoya, O. (2021). Hematological Profiles of Naturally Infected Pigs Treated with Bridelia ferruginea Leaf Extracts. Asian Hematology Research Journal, 4(2), 1-10. Retrieved from https://journalahrj.com/index.php/AHRJ/article/view/30150
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Onyenibe NS, Udogadi NS. Evaluation of antidiabetic role of Bridelia ferruginea methanol leaf extract in streptozocin induced diabetic male wistar rats. Pharma ceutical and Pharmacology International Journal. 2019;7(6):264‒269.
Wasagu RS, Adamu GM, Zaharadeen A. Phytochemical and antibacterial screening of leaf and stem bark extracts of Bridelia ferruginea. Journal of Biology, Agriculture and Healthcare. 2016;6(19):133–136.
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Busayo TA, Ebenezer OD. Effects of etha nol extract of Bridelia ferruginea on the haematological and histopathological para meters in swiss albino rats infected with Salmonella typhi. South Asian Journal of Research in Microbiology. 2020;7(2):1-18.
Oladoye SO, Ayodele ET, Idowu OT. Bryophyllum pinnatum: A mini review on ethnobotany and phytochemistry. Journal of Drugs and Pharmaceutical Science. 2018;2:1-6.
Fernandes JM, Cunha LM, Azevedo EP, Estela MG, Fernandes-Pedrosa MF, Zucolotto SM. Kalanchoe laciniata and Bryophyllum pinnatum: An updated review about ethnopharmacology, phytoche- mistry, pharmacology and toxicology. Brazilian Journal of pharmacognosy. 2019; 29:529–558.
Owoade AO, Adetutu A, Airaodion AI. Toxicological assessment of the methanolic leaf extract of Bridelia ferruginea. Journal of Phytopharmacology. 2018;7(5):419–424.
Onyenibe NS, Udogadi NS. Evaluation of antidiabetic role of Bridelia ferruginea methanol leaf extract in streptozocin induced diabetic male wistar rats. Pharma ceutical and Pharmacology International Journal. 2019;7(6):264‒269.
Wasagu RS, Adamu GM, Zaharadeen A. Phytochemical and antibacterial screening of leaf and stem bark extracts of Bridelia ferruginea. Journal of Biology, Agriculture and Healthcare. 2016;6(19):133–136.
Kolawole OM, Oguntoye SO, Agbede O, Olayemi AB. Studies on the efficacy of Bridelia ferruginea benth bark extract for domestic wastewater treatment. Bull. Chem. Soc. Ethiop. 2017;21(2):205-211.
Thomford KP, Edoh DA, Sarkodie JA. Re-evaluating the efficacy of the aqueous leaf extract of Bridelia ferrugenia and its potential combination with metformin in the management of diabetes mellitus. Journal of Medicinal Herbs and Ethnomedicine. 2015;1(1):75–78.
Oladejo AA, Otunla BJ. Evaluation of anthelmintic potential of aqueous extract of the stem bark of Bridelia ferruginea (Benth) Phyllanthaceae. Journal of Pharmaceutical Research International. 2018;24(6):1-6.
Oladejo AA, Anjorin FF, Okesola MA. Bridelia ferruginea leaf fractions ameliorates helminth infections. Clinics in Medicine. 2019;1(1):1003.
Sanchez-Vazquez MJ, Nielen M, Gunn GJ, Lewis FI. National monitoring of Ascaris suum related liver pathologies in english abattoirs: A time-series analysis, 2005-2010. Veterinary Parasitology. 2012;184: 83–87.
Shutt OA, MacDonald W. Rate of hemo globin synthesis after blood loss in sheep and influence of dietary protein. Australian Journal of Experimental Biology and Medical Science. 2015;43:475-488.
Okon JE, Esenowo GJ, Afaha IP, Umoh NS. Hematopoietic parameters of ethanolic fruits extract of musa accumulate on albino rats. Bull. Env. Pharmacol. Life Sci. 2013; 2:22-26.
Nse-Abasi NE, Williams ME, Akpabio U, Offiong EA. Haematological parameters and factors affecting their Values. Agricul tural Science. 2014;2:37-47.
Kuter DJ. Overview of blood disorders In merck manual of haematology. Harvard Medical School: Massachusetts General Hospital. 2012;82-85.
Nkafamiya II, Maina HM, Osemeahon SA, Modibbo UU. Percentage oil yield and physiochemical properties of different groundnut species (Arachis hypogaea). African Journal of Food Science. 2010; 4(7):418-421.
Urquhart GM, Armour J, Duncan JL, Dunn AM, Gennings FW. Veterinary para sitology. blackwell science Ltd. UK. 2003; 2:170-176.
Ministry of Agriculture, Fisheries and Food (MAFF). Her majesty's stationary office (HMSO); London. Manual of Veterinary Parasitological Laboratory Techniques. 1986;7–15.
Guide for the care and use of laboratory animals. NIH Publication. 1985; 85-23.
Oyedemi SC, Adewusi EA, Aiyegoro CA, Akinpelu DA. Antidiabetic and haemato logical effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin-induced diabetic wistar rats. Asian Pacific Journal of Tropical Biomedicine. 2011;1:353-358.
Nwankpa P, Chukwuemeka OG, Ekweogu CN. Investigation of ethanol stem bark extract of Treculia africana on the haematological parameters of albino wistar Rats. Journal of Biochemistry and Analy tical Biochemistry. 2017;6(4):347-351.
Isaac LJ, Abah G, Akpa B, Ekaette IU. Haematological properties of different breeds and sexes of rabbits. Proceedings of the 18th Annual Conference of Animal Science Association of Nigeria. 2013;24-27.
Ahumibe AA, Braide VB. Effect of gavage treatment with pulverized Garcina kola seeds on erythrocyte membrane integrity and selected haematological indices in male albino wistar rats. Nigerian Journal of Physiological Sciences. 2009;24:47-52.
Esenowo GJ, Sam SM, Bala DN, Ekpo BA, Edung EM. Phytochemical screening and the haematological effect of Peristrophe bicalycuta (RETZ) Nees diet preparation in albino rats. World Journal of Applied Science and Technology. 2010;2:277-281.
Ogbonnia SO, Anyika EN, Mbaka GO, Utah P, Ugwu D. Anti hyperglycaemic and anti hyperlipidaemic effects of aqueous Ethanol extract of Tapinanthus globiferus leaves and Treculia africana root bark and their mixture on alloxan diabetic rats. Agriculture and Biology Journal of North America. 2012.3:237-246.
Aprioku JS, Obianime AW. Evaluation of the effects of Citrus aurantifolia (Lime) juice in lead-induced haematological and testicular toxicities in rats. Pharmacologia. 2014;5:36-41.
Zhang W, Fievez L, Cheu E, Bureau F, Rong W, Zhang Y. Antiinflammatory effects of formoterol and ipratropium bro mide against acute cadmium-induced pulmonary inflammation in rats. The European Journal of Pharmacology. 2010;628:171-8.
Busayo TA, Ebenezer OD. Effects of etha nol extract of Bridelia ferruginea on the haematological and histopathological para meters in swiss albino rats infected with Salmonella typhi. South Asian Journal of Research in Microbiology. 2020;7(2):1-18.
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