Multiple Infectious Intracranial Aneurysms in a Child with Acute Lymphoblastic Leukaemia - A Fatal Complication in a Highly Curable Disease
Asian Hematology Research Journal,
Page 11-17
Abstract
Multiple infectious intracranial aneurysms are rare in the paediatric population. This case report is of a child with acute lymphoblastic leukaemia who developed this fatal complication in induction therapy. The child succumbed despite aggressive medical management and surgical intervention. A high index of suspicion is required in the early diagnosis and treatment when a child presents with febrile neutropenia and intracranial haemorrhage.Lymphoblastic leukaemia
Keywords:
- Lymphoblastic leukaemia
- intracranial aneurysms
- childhood malignancy.
How to Cite
Krishnan, Y., Gazel, S., Kurup, S., & Muralikrishnan, V. P. (2021). Multiple Infectious Intracranial Aneurysms in a Child with Acute Lymphoblastic Leukaemia - A Fatal Complication in a Highly Curable Disease. Asian Hematology Research Journal, 4(2), 11-17. Retrieved from https://journalahrj.com/index.php/AHRJ/article/view/30151
References
Flores BC, Patel AR, Braga BP et al. Management of infectious intracranial aneurysms in the pediatric population. Childs Nerv Syst. 2016;32(7):1205-17.
Kannoth S, Iyer R, Thomas SV, et al. Intracranial infectious aneurysm: presentation, management and outcome. J Neurol Sci. 2007;256(1-2):3-9.
Osler W. The Gulstonian lectures, on malignant endocarditis. Br Med J. 1885; 1(1264):577–579
Parkhurst GF, Dekcer JP. Bacterial aortitis and mycotic aneurysm of the aorta; A report of twelve cases. Am J Pathol. 1955; 31:821-35.
Chen YF, Lin PY, Yen HW, et al. Double mycotic aneurysms of the ascending aorta. Ann Thorac Surg. 1997;63:529-31.
Fisk M, Peck LF, Miyagi K, et al. Mycotic aneurysms: A case report, clinical review and novel imaging strategy. QJM: An International Journal of Medicine. 2012; 105(2):181–188.
Allen LM, Fowler AM, Walker C, et al. Retrospective review of cerebral mycotic aneurysms in 26 patients: focus on treatment in strongly immunocompromised patients with a brief literature review. AJNR Am J Neuroradiol. 2013;34(4):823-827.
Rinne J, Hernesniemi J, Puranen M, et al. Multiple intracranial aneurysms in a defined population: prospective angiographic and clinical study. Neurosurgery. 1994;35(5):803-808.
Khormi YH, Tyndall RG, Tamber M. Malignant clinical course of mycotic intracranial aneurysms in children: A review. Surg Neurol Int. 2020;11:71.
Müller BT, Wegener OR, Grabitz K, et al. Mycotic aneurysms of the thoracic and abdominal aorta and iliac arteries: experience with anatomic and extra-anatomic repair in 33 cases. J Vasc Surg. 2001;33(1):106-113.
Karsner HT. Acute Inflammation of Arteries. Springfield. III: Charles C Thomas Publishing. 1947;16.
Sahu KK, Yanamandra U, Dhawan R, et al. Fungal Mycotic Aneurysm in a Case of Acute Lymphoblastic Leukemia. Indian J Hematol Blood Transfus. 2016;32 (Suppl1):32-37.
Zingale A, Chiaramonte I, Albanese V, et al. Infected cerebral hemorrhage by ruptured infectious anterior communicating artery giant aneurysm in a patient with T cell acute lymphoblastic leukemia. Case report. J Neurosurg Sci. 1997;41(4):395-400.
Khera S, Simalti AK, Balasubramaniam D, et al. Rasmussen's aneurysm in a child with acute lymphoblastic leukaemia. BMJ Case Rep. 2020;13(6):e235399.
Shen G, Shen X, Pu W, et al. Imaging of cerebrovascular complications of infection. Quant Imaging Med Surg. 2018;8(10): 1039-1051.
Oderich GS, Panneton JM, Bower TC, et al. Infected aortic aneurysms: aggressive presentation, complicated early outcome, but durable results. J Vasc Surg. 2001;34 (5):900-908.
Larry M Baddour, Walter R Wilson et al. Infective endocarditis: Diagnosis, antimicrobial therapy and management of complications: a statement for healthcare professionals from the committee on rheumatic fever, endocarditis, and kawasaki disease, council on cardiovascular disease in the young, and the councils on clinical cardiology, stroke, and cardiovascular surgery and anesthesia. American heart association: endorsed by the infectious diseases society of America. Circulation. 2005;111 (23):e394-43420.
Wai-Kit Lee, Peter J, Mossop, et al. Infected (Mycotic) aneurysms: Spectrum of imaging appearances and management. Radio Graphics. 2008;28:1853–1868
Barrow DL, Prats AR. Infectious intracranial aneurysms: comparison of groups with and without endocarditis. Neurosurgery. 1990;27:562–72.
Vajda J. Multiple intracranial aneurysms: a high risk condition. Acta Neurochir. 1992; 118(1-2): 59-75.
Rice CJ, Cho SM, Marquardt RJ, et al. Clinical course of infectious intracranial aneurysm undergoing antibiotic treatment. J Neurol Sci. 2019;403:50-55.
Kannoth S, Iyer R, Thomas SV, et al. Intracranial infectious aneurysm: presentation, management and outcome. J Neurol Sci. 2007;256(1-2):3-9.
Osler W. The Gulstonian lectures, on malignant endocarditis. Br Med J. 1885; 1(1264):577–579
Parkhurst GF, Dekcer JP. Bacterial aortitis and mycotic aneurysm of the aorta; A report of twelve cases. Am J Pathol. 1955; 31:821-35.
Chen YF, Lin PY, Yen HW, et al. Double mycotic aneurysms of the ascending aorta. Ann Thorac Surg. 1997;63:529-31.
Fisk M, Peck LF, Miyagi K, et al. Mycotic aneurysms: A case report, clinical review and novel imaging strategy. QJM: An International Journal of Medicine. 2012; 105(2):181–188.
Allen LM, Fowler AM, Walker C, et al. Retrospective review of cerebral mycotic aneurysms in 26 patients: focus on treatment in strongly immunocompromised patients with a brief literature review. AJNR Am J Neuroradiol. 2013;34(4):823-827.
Rinne J, Hernesniemi J, Puranen M, et al. Multiple intracranial aneurysms in a defined population: prospective angiographic and clinical study. Neurosurgery. 1994;35(5):803-808.
Khormi YH, Tyndall RG, Tamber M. Malignant clinical course of mycotic intracranial aneurysms in children: A review. Surg Neurol Int. 2020;11:71.
Müller BT, Wegener OR, Grabitz K, et al. Mycotic aneurysms of the thoracic and abdominal aorta and iliac arteries: experience with anatomic and extra-anatomic repair in 33 cases. J Vasc Surg. 2001;33(1):106-113.
Karsner HT. Acute Inflammation of Arteries. Springfield. III: Charles C Thomas Publishing. 1947;16.
Sahu KK, Yanamandra U, Dhawan R, et al. Fungal Mycotic Aneurysm in a Case of Acute Lymphoblastic Leukemia. Indian J Hematol Blood Transfus. 2016;32 (Suppl1):32-37.
Zingale A, Chiaramonte I, Albanese V, et al. Infected cerebral hemorrhage by ruptured infectious anterior communicating artery giant aneurysm in a patient with T cell acute lymphoblastic leukemia. Case report. J Neurosurg Sci. 1997;41(4):395-400.
Khera S, Simalti AK, Balasubramaniam D, et al. Rasmussen's aneurysm in a child with acute lymphoblastic leukaemia. BMJ Case Rep. 2020;13(6):e235399.
Shen G, Shen X, Pu W, et al. Imaging of cerebrovascular complications of infection. Quant Imaging Med Surg. 2018;8(10): 1039-1051.
Oderich GS, Panneton JM, Bower TC, et al. Infected aortic aneurysms: aggressive presentation, complicated early outcome, but durable results. J Vasc Surg. 2001;34 (5):900-908.
Larry M Baddour, Walter R Wilson et al. Infective endocarditis: Diagnosis, antimicrobial therapy and management of complications: a statement for healthcare professionals from the committee on rheumatic fever, endocarditis, and kawasaki disease, council on cardiovascular disease in the young, and the councils on clinical cardiology, stroke, and cardiovascular surgery and anesthesia. American heart association: endorsed by the infectious diseases society of America. Circulation. 2005;111 (23):e394-43420.
Wai-Kit Lee, Peter J, Mossop, et al. Infected (Mycotic) aneurysms: Spectrum of imaging appearances and management. Radio Graphics. 2008;28:1853–1868
Barrow DL, Prats AR. Infectious intracranial aneurysms: comparison of groups with and without endocarditis. Neurosurgery. 1990;27:562–72.
Vajda J. Multiple intracranial aneurysms: a high risk condition. Acta Neurochir. 1992; 118(1-2): 59-75.
Rice CJ, Cho SM, Marquardt RJ, et al. Clinical course of infectious intracranial aneurysm undergoing antibiotic treatment. J Neurol Sci. 2019;403:50-55.
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