Role of Taurine in Children with Anaemia
Asian Hematology Research Journal,
Iron deficiency (ID) is the most common health problem noted in paediatric population. The prevalence of anaemia in India among paediatric group is 23.5% in 5-7 years and 58.7% in children below 5 years. The major cause of ID in children is low intake of iron from the actual requirement. ID results in iron deficiency anaemia (IDA) which impacts energy production resulting in fatigue, and depletion of muscle stores. Iron is cofactor for energy production enzyme in the tricarboxylic acid cycle and synthesis of carnitine (which carries fatty acids across the mitochondrial membrane). Iron also plays a crucial role in enzyme rate-limiting step for gluconeogenesis, and plays a role in the function of certain neurotransmitter amines. Fatigue is the cardinal symptom of anaemia due to increased ID. Taurine is an amino acid present in mammalian tissue, most abundantly found in skeletal muscle. Muscle senescence and atrophy may decline the taurine concentrations, alters iron metabolism and increases oxidative injury. Therefore, a causal relationship may exist between taurine and iron metabolism in muscle health and disease. Iron preparations are major stand-by for the treatment of IDA; however, these preparations are associated with gastric side-effects. In anaemic patients, taurine along with iron supplementation is reported to: Enhance red blood cells (RBC) membrane stabilization, osmoregulation, and detoxification, Decrease GI related side effects of iron salts (anti-oxidant and anti-inflammatory effect), By building up energy, can give symptomatic relief from lethargy and weakness, Enhance light chain ferritin isoform (FTL) involved in cellular iron storage. Therefore, combination of taurine with iron may result in improved lethargy and increased iron stores in skeletal muscles resulting in treatment of IDA and associated cardinal symptom, fatigue.
- Iron deficiency
- iron deficiency anaemia
How to Cite
Rahman M, Chauhan S, Patel R, Boro B, Anwar T, Kumar P, Muhammad T, Srivastava S. Anaemia among Indian children: A study of prevalence and associated factors among 5–9 years old. Children and Youth Services Review. 2020;119:105529.
Dutta M, Bhise M, Prashad L, Chaurasia H, Debnath P. Prevalence and risk factors of anemia among children 6–59 months in India: A multilevel analysis. Clinical Epidemiology and Global Health. 2020;8:868–878.
Onyeneho NG, Ozumba BC, Subramanian SV. Determinants of childhood anemia in India. Sci Rep. 2019;9(1):16540.
Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. Lancet. 2016;387(10021):907-16.
Cappellini MD, Musallam KM, Taher AT. Iron deficiency anaemia revisited. J Intern Med. 2020;287(2):153-170.
Eichner ER. Fatigue of anemia. Nutr Rev. 2001;59(1 Pt 2):S17-9.
Willis WT, Gohil K, Brooks GA, Dallman PR. Iron deficiency: Improved exercise performance within 15 hours of iron treatment in rats. J Nutr. 1990;120(8):909-16.
Bager P. Fatigue and acute/chronic anaemia. Dan Med J. 2014;61(4):B4824.
Seidel U, Lüersen K, Huebbe P, Rimbach G. Taurine enhances iron-related proteins and reduces lipid peroxidation in differentiated c2c12 myotubes. Antioxidants (Basel). 2020;9(11):1071.
Sturman JA, Chesney RW. Taurine in pediatric nutrition. Pediatr Clin North Am. 1995;42(4):879-97.
Özdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk Pediatri Ars. 2015;50(1):11-9.
Verner A, Craig S, McGuire W. Effect of taurine supplementation on growth and development in preterm or low birth weight infants. Cochrane Database Syst Rev. 2007;(4):CD006072.
Higgins JP, Tuttle TD, Higgins CL. Energy beverages: Content and safety. Mayo Clin Proc. 2010;85(11):1033-41.
Faruqui AA. Anaemia and fatigue: Role of taurine. Asian Hematology Research Journal. 2020;3(4):41-48.
Sirdah MM, Abushahla AK, Al-Sarraj HA. Effect of the addition of the antioxidant taurine on the complete blood count of whole blood stored at room temperature and at 4ºC for up to 7 days. Rev Bras Hematol Hemoter. 2013;35(1): 44-51.
Marcinkiewicz J, Kontny E. Taurine and inflammatory diseases. Amino Acids. 2014;46(1):7-20.
Schaffer S, Kim HW. Effects and mechanisms of taurine as a therapeutic agent. Biomol Ther (Seoul). 2018;26(3):225-241.
Abstract View: 16 times
PDF Download: 18 times