Haematological Indices of HIV-1 Infected Subjects on Antiretroviral Therapy from Selected Tertiary Hospitals in Port Harcourt, Nigeria
Asian Hematology Research Journal,
Introduction: Changes in haematological indices could result from so many underlining factors, one of which could be an autoimmune response, defect in hemopoiesis, infection, cancer, and so on. Cytopenia is a common illness observable in the blood of people infected with HIV.
Materials and Methods: This is a cross-sectional study involving two hundred patients. The blood samples of recruited subjects were collected aseptically before analysis for Haematology indices using Mindray BC-6800.
Results: Results showed that the lowest and highest count/L for haematological indices were; WBC 1.3-11.9 x109/L, Lymphocyte 0.3-6.4 x109/L, Monocyte 0.2-2.6 x109/L, Granulocyte 0.1-5.1 x109/L and Platelet 30-550 x109/L. White blood cell indices showed a significant difference in distribution of relative lymphocytes (Mean+SD 50.78+15.69) (P=0.000), Monocytes (Mean+SD 15.929+8.68) (P=0.000), Granulocytes (Neutrophils, Basophil and Eosinophil) (Mean+SD 33.287+18.05) (P=0.000), and absolute counts of lymphocytes (Mean+SD 2.742+1.14) (P=0.000), Monocytes (Mean+SD 0.838+0.48) (P=0.000), Granulocytes (Neutrophils, Basophil and Eosinophil) (Mean+SD 1.943+1.31) (P=0.000). Red blood cell indices showed a significant difference in their distribution across all ages in this study. Haemoglobin concentration (Mean+SD 10.491+2.30) (P=0.000), Haemoglobin crit (Mean+SD 40.52+6.98) (P=0.000), MCV (Mean+SD 92.03+6.68) (P=0.000), MCH (Mean+SD 23.43+2.32) (P=0.001), PLT x109/L (Mean+SD 223.10+84.52) (P=0.000), PDW (Mean+SD 13.04+5.23) (P=0.000). Similarly, age was a significant factor in the distribution of haematological parameters across all blood cell lines as it showed significant differences in white blood cell count, relative and absolute counts for Lymphocytes, monocytes, and granulocytes.
Conclusion: The study showed a substantial change in the WBC differential counts of study participants based on the duration of antiviral drug intake.
How to Cite
Fan L, Cuilin L, Zhao H. Prevalence and risk factors of cytopenia in HIV-infected patients before and after the initiation of HAART. BioMed Research International. 2020;3132589.
Available:https://doi.org/10.1155/2020/3132589 on 14th June 2021.
Falck S, Holland K. What is cytopenia?; 2018.
Williams GP. HIV Prevention and treatment strategies for HIV infection. 2013;41(8):470-473.
Woodham WA, Skeate JG, Sanna AM, Taylor JR, Da Silva DM, Cannon PM, Kast WM. Human immunodeficiency virus immune cell receptors, coreceptors, and cofactors: Implications for prevention and treatment. AIDS Patient Care STDS. 2016;30(7):291–306.
World Health Organization. HIV report on Nigeria; 2014.
Available:www.who.hiv-fact-sheet/nigeria on 23th October, 2019.
Sharma R, Nalepa G. Evaluation and management of chronic pancytopenia. pediatrics in review. 2016;37(3):101–113.
Belperio PS, Rhew DC. Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: A systematic review of the literature. The American Journal of Medicine. 2004;116(7):27–43.
Dikshit B, Wanchu A, Sachdeva RK, Sharma A, Das R. Profile of hematological abnormalities of Indian HIV infected individuals. BMC Hematology. 2009;9(1): 5.
Kyeyune R, Saathoff E, Ezeamama AE, Löscher T, Fawzi W, Guwatudde D. Prevalence and correlates of cytopenias in HIV-infected adults initiating highly active antiretroviral therapy in Uganda. BMC Infectious Diseases. 2014;14(1):496.
Marchionatti A, Parisi MM. Anemia and thrombocytopenia in people living with HIV/AIDS: a narrative literature review. Int Health. 2021;13(2):98-109.
Asemota EA, Okafor IM, Okoroiwu HU, Ekong ER, Anyanwu SO, Effiong EE, Udomahc F. Zinc, copper, CD4 T-cell count and some hematological parameters of HIV-infected subjects in Southern Nigeria. Integrate Medical Research. 2018;7(1):53–60.
Odhiambo C, Zeh C, Ondoa P, Omolo P, Akoth B, Lwamba H, Lando R, Williamson J, Otieno J, Masaba R, Weidle P, Thomas T, Ki BS Study Team. Anemia and red blood cell abnormalities in HIV-infected and HIV-exposed breastfed infants: A secondary analysis of the kisumu breastfeeding study. PLoS ONE. 2015;10(11):e0141599.
Available:https://doi.org/10.1371/journal.pone.0141599 on 16th June 2021.
Okoye AA, Picker LJ. CD4+ T cell depletion in HIV infection: Mechanisms of immunological failure. Immunological Review. 2014;254(1):54–64.
Pennap GR, Abubakar K. Prevalence of anemia among human immunodeficiency virus-infected patients accessing healthcare in federal medical center Keffi, Nigeria. International Journal of Tropical Disease Health. 2015;10(3):1–7.
Rodriguez-Penney AT, Iudicello JE, Riggs KR, Doyle K, Ellis J, Letendre SL, Grant I, Woods S. Co-Morbidities in persons infected with HIV: Increased burden with older age and negative effects on health-related quality of life. AIDS Patient Care STDS. 2013;27(1):5–16.
Rojas J, Blanco JL, Marcos MA, Lonca M, Tricas A, Moreno L, Gonzalez-Cordon A, Torres B, Mallolas J, Garcia F, Gatell JM, Martinez E. Dolutegravir monotherapy in HIV-infected patients with sustained viral suppression. Journal of Antimicrobial Chemotherapy. 2016;71:1975–1981.
WHO. HIV/AIDS: When to start ART in adults and adolescents. Consolidated ARV guidelines; 2013.
Available:https://www.who.int/hiv/pub/guidelines/arv2013/art/statartadolescents/en/ on 09/01/2021
National Population Commission. The 2006 Nigeria demographic and health survey. Federal Republic of Nigeria, Abuja, Nigeria; 2006.
Available:www.npc.gov.ng on 13 January, 2021.
Shenzhen-Mindray. Mindray BC-6800 Auto Haematology analyzer system, Shenzhen Mindray Bio-Medical Electronics Co Ltd; 2017.
Parinitha, Kulkarni. Haematological changes in HIV infection with correlation to CD4 cell count. Australian Medical Journal, 2012;5(3):157-162.
Alemu A, Shiferaw Y, Addis Z, Mathewos B, Birhan W. Effect of malaria on HIV/AIDS transmission and progression. BMC Springer Nature Parasites & Vectors. 2013;6:18.
Cheesbrough M. District laboratory practice in tropical countries part 1. 2nd Edition, Cambridge University Press, Cambridge. 2009;195-216.
Osaro E, Abdullahi A, Tosan E, Adias TC. Risk factors associated with malaria infection among pregnant women of African Descent in Specialist Hospital Sokoto, Nigeria. Obstetrics & Gynecology International Journal. 2019;10(4):132-131. Available:https://medcraveonline.com/OGIJ/risk-factors-associated-with-malaria-infection-among-pregnant-women-of-african-descent-in-specialist-hospital-sokoto-nigeria.html
Centre for Disease Control and Prevention (CDC, 2020). HIV Treatment.
Available:https://www.cdc.gov/hiv/basics/livingwithhiv/treatment.html on 09/01/2021.
Centre for Disease Control and Prevention (CDC, 2020). HIV/AIDS.
Available:https://www.cdc.gov/hiv/basics/whatishiv.html. Retrieved 1/12/2020.
Centre for Disease Control and Prevention. (CDC, 2014). HIV in the United States: the stages of care—CDC Fact Sheet.
Accessed 1/12/ 2019.
Ezechi O, Kalejaiye O, Gab-Okafor C. The burden of anaemia and associated factors in HIV positive Nigerian women. Archives of Gynecology and Obstetrics. 2013;287(2).
Gebremedhin KB, Haye TB Factors associated with anemia among people living with HIV/AIDS taking ART in Ethiopia. Advanced Haematology. 2019;1–8.
German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’. Human immunodeficiency virus (HIV). Transfusion Medicine & Chemotherapy. 2016;43(3):203–222.
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