Assessment of Renal Functions among Sudanese Patients with Acute Lymphoblastic Leukemia's Receiving Chemotherapy in Radiation and Isotopes Center of Khartoum (RICK), Sudan
Asian Hematology Research Journal,
Page 16-22
Abstract
Background: A wide array of disturbances in electrolyte equilibrium is commonly seen in patients with acute leukemia (AL). These abnormalities present a potential hazard in these patients, as that of enhancing the cardio-toxic effects of certain chemotherapeutic regimens.
Materials and Methods: This study was designed as interventional study, which includes 50 samples, the data was collected form hospital archives, include both male and female (the males is 24 with 48% while the rests 26 is females with 52%), from different area in Sudan (east is 2%, west is 64%, north is 10%, south is 12%, and center is 12%), have different classification of Acute Lymphoblastic Leukemia's (L1 is 17 with 34%, L2 is 27 with 54% and L3 is 6 with 12%). Carried out in Radiation and Isotopes Center of Khartoum in Khartoum state, during the period from February 2020 to January 2021, and the obtained data were analyzed by SPSS.
Results: The result of this study showed that there was insignificant difference (p 0.05) in the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, and magnesium in the study groups before and after treatment, and significant increase in the serum level of potassium in the study groups after treatment p. value of 0.007, the mean of serum level of potassium before and after treatment is 2.688 and 3.702 respectively. And insignificant difference (p 0.05) in the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, potassium and magnesium in the study groups before and after treatment according to gender and FAB classification.
Conclusion: The study conclude that the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, and magnesium was not affected by treatment, but the potassium is increased after treatment. And the gender and classification of Acute Lymphoblastic Leukemia's have insignificant effect on the serum levels of urea, creatinine, uric acid, sodium, calcium, phosphorous, potassium and magnesium.
Keywords:
- Acute Lymphoblastic Leukemia's
- urea
- creatinine
- uric acid
- sodium
- potassium
- calcium
- magnesium
- phosphorous
- Sudanese
How to Cite
References
Ondreyco SM, Kjeldsberg CR, Fineman RM, Vaninetti S, Kushner JP. Monoblastic transformation in chronic myelogenous leukemia: presentation with massive hepatic involvement. Cancer. 1981;48(4):957-963.
Bruguera M, Miquel R. The Effect of Haematological and Lymphatic Diseases on the Liver. Textbook of Hepatology: From Basic Science to Clinical Practice. 2007;1662-1670.
Abdalla AA, Akash, R. Liver Enzymes, Urea and Creatinine among Acute Lymphocytic Leukemia in Sudanese Patients. Journal of Medical and Biological Science Research. 2018;4(2):72-75.
Litten JB, Rodríguez MM, Maniaci V. Acute lymphoblastic leukemia presenting in fulminant hepatic failure. Pediatric Blood & Cancer. 2006;47(6):842-845.
Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison's principles of internal medicine. McGraw Hill; 2001.
Shimizu T, Tajiri T, Akimaru K, Arima Y, Yokomuro S, Yoshida H, Mamada Y, Taniai N, Mizuguchi Y, Kawahigashi Y, Naito Z.. Cholecystitis caused by infiltration of immature myeloid cells: a case report. Journal of Nippon Medical School. 2006;73(2):97-100.
Munker R, Hill U, Jehn U, Kolb HJ, Schalhorn A. Renal complications in acute leukemias. Haematologica. 1998;83(5): 416-421.
Lommatzsch SE, Bellizzi AM, Cathro HP, Rosner MH. Acute renal failure caused by renal infiltration by hematolymphoid malignancy. Annals of Diagnostic Pathology. 2006;10(4):230-234.
American Cancer Society. How is leukemia diagnosed? Detailed guide; 2010: Leukemia-Adult Chronic. American Cancer Society. Archived from the Original; 2010.
Ross JA, Kasum CM, Davies SM, Jacobs DR, Folsom AR, Potter JD. Diet and risk of leukemia in the Iowa Women’s Health Study. Cancer Epidemiol Biomarkers Prev. 2002;11(8):777-81.
Salman BS, Ali KF, Alwan AF. Evaluation of ELectrolytes in adult patients with acute leukemia before and after chemotherapy. Baghdad Sci J. 2013;10(2):362-7.
Abdalla AA, Akasha R. Liver enzymes, urea and creatinine among acute lymphocytic leukemia in Sudanese patients. J Med Biol Sci Res. 2018;4(2):72-5.
5. Matti BF. Shahla'a Fadhil Sabir, Maysaa Ali Abdul Khaleq, Marwah Hasan Al kaabi. 2017. Serum Calcium and Phosphateleveelsin Patients with Chronic Myeloid Leukemia Taking Different Dose of Tyrosine Kinase Inhibitors. AJPS;17(1): 12-6.
Filippatos TD, Milionis HJ, Elisaf MS. Alterations in electrolyte equilibrium in patients with acute leukemia. Eur J Haematol. 2005;75(6):449-460.
Lantz B, Carlmark B, Reizenstein P. Electrolytes and whole body potassium in acute leukemia. Acta Med Scand. 1979;206(1-2):45-50.
Milionis HJ, Bourantas CL, Siamopoulos KC, Elisaf MS. Acid-base and electrolyte abnormalities in patients with acute leukemia. Am J Hematol. 1999;62(4):201-207.
Zamkoff KW, Kirshner JJ. Marked hypophosphatemia associated with acute myelomonocytic leukemia. Indirect evidence of phosphorus uptake by leukemic cells. Arch Intern Med. 1980; 140(11): 1523-1524.
Noguchi M, Oshimi K. Extensive bone marrow necrosis and symptomatic hypercalcemia in B cell blastic transformation of chronic myeloid leukemia: report of a case and review of the literature. Acta Haematol. 2007;118(2): 111-116.
-
Abstract View: 30 times
PDF Download: 11 times
