Paraoxonase-1 L/M 55 Gene Polymorphısm in the Cases of Prımer Immune Thrombocytopenıa
Asian Hematology Research Journal,
Page 26-36
Abstract
Background: Oxidative stress and free-radicals could be responsible the pathogenesis and prognosis of primer immune thrombocytopenia (ITP). Paraoxonase-1 (PON-1) is an antioxidative feature. In this study, it had investigated that the role of PON-1 Leu (L)/Met (M) 55 gene polymorphism in etiopathogenesis of ITP, course of disorder and its effects of the therapy. Here, for the first time, we described polymorphisms in patients with ITP.
Materials and Methods: 51 patients with newly diagnosed ITP (ND-ITP), 15 patients with chronic ITP (CH-ITP) and 60 healthy controls (HC) were investigated.
Results: Most common genotype in all patients with ITP, ND-ITP and CH-ITP group, HC group was LM genotype, while MM genotype was found lower in all groups. The frequency of L allel in CH-ITP group were higher. For ND-ITP group, the frequency of M allel were higher than the frequency of CH-ITP group. Individuals with a LM genotype were found to be more resistive to anti-D therapy. It is recommended to use HDMP or IVIG for patients with LL and LM genotype and only IVIG for patients with MM genotype.
Conclusion: PON-1 L/M 55 gene polymorphism in the cases of ITP displayed differences when compared those of controls. It could effect course of disorder, even might change response of treatment.
Keywords:
- Primer immune thrombocytopenia
- paraoxonase-1
- L/M 55 gene
- polymorphism
How to Cite
Akarsu, S., Cakici, O., & Erol, D. (2023). Paraoxonase-1 L/M 55 Gene Polymorphısm in the Cases of Prımer Immune Thrombocytopenıa. Asian Hematology Research Journal, 7(2), 26-36. Retrieved from https://journalahrj.com/index.php/AHRJ/article/view/30218
References
Jin CQ, Dong HX, Cheng PP, Zhou JW, Zheng BY, Liu F. Antioxidant status and oxidative stress in patients with chronic ITP. Scand J Immunol. 2013;77:482-487.
Bae SC, Lee YH. Associations between paraoxonase-1 and systemic lupus erythematosus. Lupus. 2019;28(13):1571-1576.
Cura M, Koç A, Aksoy N, Özdemir ZC. Effect of short-term, high-dose methylprednisolone on oxidative stress in children with acute immune thrombocytopenia. Blood Research. 2016; 51:261-267.
Kulka M. A review of paraoxonase 1 properties and diagnostic applications. Pol J Vet Sci. 2016;19:225-232.
Bacchetti T, Ferretti G, Sahebkar A. The role of paraoxonase in cancer. Semin Cancer Biol. 2019;56:72-86.
Kotur-Stevuljević J, Vekić J, Stefanović A, Zeljković A, Ninić A, Ivanišević J, Miljković M, Sopić M, Munjas J, Mihajlović M, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V. Paraoxonase 1 and atherosclerosis-related diseases. Biofactors. 2020;46(2):193-205.
Reichert CO, de Macedo CG, Levy D, Sini BC, Monteiro AM, Gidlund M, Maselli LMF, Gualandro SFM, Bydlowski SP. Paraoxonases (PON) 1, 2, and 3 Polymorphisms and PON-1 Activities in Patients with Sickle Cell Disease. Antioxidants (Basel). 2019;8(8):252.
Deng Z, Xiang H, Gao W. Significant association between paraoxonase 1 rs662 polymorphism and coronary heart disease: A meta-analysis in the Chinese population. Herz. 2020;45(4):347-355.
Leviev I, Deakin S, James RW. Decreased stability of the M54 isoform of paraoxonase as a contributory factor to variations in human serum paraoxonase concentrations. J Lipid Res. 2001;42:528-535.
Grace RF, Long M, Kalish LA, Neufeld EJ. Applicability of 2009 international consensus terminology and criteria for immune thrombocytopenia to a clinical pediatric population. Pediatr Blood Cancer. 2012;58(2):216-220.
Provan D, Arnold DM, Bussel JB, Chong BH, Cooper N, Gernsheimer T, Ghanima W, Godeau B, González-López TJ, Grainger J, Hou M, Kruse C, McDonald V, Michel M, Newland AC, Pavord S, Rodeghiero F, Scully M, Tomiyama Y, Wong RS, Zaja F, Kuter DJ. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3(22):3780-3817.
DeSouza S, Angelini D. Updated guidelines for immune thrombocytopenic purpura: Expanded management options. Cleve Clin J Med. 2021;88(12):664-668.
Çınar E, Akgöllü E, Yücebilgiç G, Bilgin R, Paydaş S. The effect of Paraoxonase gene polymorphisms and paraoxonase enzyme activity on Non-Hodgkin lymphoma. Nucleosides Nucleotides Nucleic Acids. 2022;41(5-6):489-502.
Wentworth P, Jr Jones LH, Wentworth AD, Zhu X, Larsen NA, Wilson IA, Xu X, Goddard WA, Janda KD, Eschenmoser A, Lerner RA. Antibody catalysis of oxidation of water. Science 2001;293:1806-1811.
Zhang B, Zehnder JL. Oxidative stress and immune thrombocytopenia. Semin Hematol 2013;50:e1-4.
Zhang B, Lo C, Shen L, Sood R, Jones C, Cusmano-Ozog K, Park-Snyder S, Wong W, Jeng M, Cowan T, Engleman EG, Zehnder JL. The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP. Blood 2011; 117:4569-4579.
Pehlivan M, Okan V, Sever T, Balci SO, Yilmaz M, Babacan T, Pehlıvan S. Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura. Platelets 2011;22:588-595.
Bacchetti T, Vignini A, Giulietti A, Nanetti L, Provinciali L, Luzzi S, Mazzanti L, Ferretti G. Higher Levels of Oxidized Low Density Lipoproteins in Alzheimer's Disease Patients: Roles for Platelet Activating Factor Acetyl Hydrolase and Paraoxonase-1. J Alzheimers Dis. 2015;46(1):179-86.
Hong-Liang L, De-Pei L, Chihj-Chuan L. Paraoxonase gene polymorphisms, oxidative stress and diseases. J Mol Med. 2003;81:766-779.
Ściskalska M, Milnerowicz H. Importance of Polymorphisms in the Gene of Paraoxonase-1 (SNP rs662) and Apolipoprotein A-I (SNP rs670 and rs5069) in Non-Smoking and Smoking Healthy Subjects and Patients with Acute Pancreatitis. Genes (Basel). 2022;13(11):1968.
Dardiotis E, Aloizou AM, Siokas V, Tsouris Z, Rikos D, Marogianni C, Aschner M, Kovatsi L, Bogdanos DP, Tsatsakis A. Paraoxonase-1 genetic polymorphisms in organophosphate metabolism. Toxicology. 2019;411:24-31.
Delgado AJ, Ames PR, Donohue S, Stanyer L, Nourooz-Zadeh J, Ravirajan C, Isenberg DA. Antibodies to highdensity lipoprotein and beta2-glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome. Arthritis Rheum. 2003;48:284-296.
Kovacs TJ, Harris S, Vas TK, Seres I, Short CD, Wittmann IK, Paragh G, Mackness MI, Mackness B, Durrington PN, Nagy JM, Brenchley PEC. Paraoxonase gene polymorphism and serum activity in progressive IgA nephropathy. J Nephrol. 2006;19:732-738.
Hashemi MM, Mousavi E, Arab-Bafrani Z, Nezhadebrahimi A, Marjani A. The Most Effective Polymorphisms of paraoxonase-1 Gene on Enzyme Activity and Concentration of paraoxonase-1 Protein in Type 2 Diabetes Mellitus Patients and Non-Diabetic Individuals: A Systematic Review and Meta-Analysis. Diabetes Res Clin Pract..2019;152:135-145.
Agachan B, Yilmaz H, Ergen HA, Karaali ZE, Isbir T. Paraoxonase (PON1) 55 and 192 Polymorphism and Its Effects to Oxidant-Antioxidant System in Turkish Patients with Type 2 Diabetes Mellitus. Physiol Res. 2005;54:287-293.
Bae SC, Lee YH. Associations between paraoxonase-1 and systemic lupus erythematosus. Lupus. 2019;28(13):1571-1576.
Cura M, Koç A, Aksoy N, Özdemir ZC. Effect of short-term, high-dose methylprednisolone on oxidative stress in children with acute immune thrombocytopenia. Blood Research. 2016; 51:261-267.
Kulka M. A review of paraoxonase 1 properties and diagnostic applications. Pol J Vet Sci. 2016;19:225-232.
Bacchetti T, Ferretti G, Sahebkar A. The role of paraoxonase in cancer. Semin Cancer Biol. 2019;56:72-86.
Kotur-Stevuljević J, Vekić J, Stefanović A, Zeljković A, Ninić A, Ivanišević J, Miljković M, Sopić M, Munjas J, Mihajlović M, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V. Paraoxonase 1 and atherosclerosis-related diseases. Biofactors. 2020;46(2):193-205.
Reichert CO, de Macedo CG, Levy D, Sini BC, Monteiro AM, Gidlund M, Maselli LMF, Gualandro SFM, Bydlowski SP. Paraoxonases (PON) 1, 2, and 3 Polymorphisms and PON-1 Activities in Patients with Sickle Cell Disease. Antioxidants (Basel). 2019;8(8):252.
Deng Z, Xiang H, Gao W. Significant association between paraoxonase 1 rs662 polymorphism and coronary heart disease: A meta-analysis in the Chinese population. Herz. 2020;45(4):347-355.
Leviev I, Deakin S, James RW. Decreased stability of the M54 isoform of paraoxonase as a contributory factor to variations in human serum paraoxonase concentrations. J Lipid Res. 2001;42:528-535.
Grace RF, Long M, Kalish LA, Neufeld EJ. Applicability of 2009 international consensus terminology and criteria for immune thrombocytopenia to a clinical pediatric population. Pediatr Blood Cancer. 2012;58(2):216-220.
Provan D, Arnold DM, Bussel JB, Chong BH, Cooper N, Gernsheimer T, Ghanima W, Godeau B, González-López TJ, Grainger J, Hou M, Kruse C, McDonald V, Michel M, Newland AC, Pavord S, Rodeghiero F, Scully M, Tomiyama Y, Wong RS, Zaja F, Kuter DJ. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3(22):3780-3817.
DeSouza S, Angelini D. Updated guidelines for immune thrombocytopenic purpura: Expanded management options. Cleve Clin J Med. 2021;88(12):664-668.
Çınar E, Akgöllü E, Yücebilgiç G, Bilgin R, Paydaş S. The effect of Paraoxonase gene polymorphisms and paraoxonase enzyme activity on Non-Hodgkin lymphoma. Nucleosides Nucleotides Nucleic Acids. 2022;41(5-6):489-502.
Wentworth P, Jr Jones LH, Wentworth AD, Zhu X, Larsen NA, Wilson IA, Xu X, Goddard WA, Janda KD, Eschenmoser A, Lerner RA. Antibody catalysis of oxidation of water. Science 2001;293:1806-1811.
Zhang B, Zehnder JL. Oxidative stress and immune thrombocytopenia. Semin Hematol 2013;50:e1-4.
Zhang B, Lo C, Shen L, Sood R, Jones C, Cusmano-Ozog K, Park-Snyder S, Wong W, Jeng M, Cowan T, Engleman EG, Zehnder JL. The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP. Blood 2011; 117:4569-4579.
Pehlivan M, Okan V, Sever T, Balci SO, Yilmaz M, Babacan T, Pehlıvan S. Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura. Platelets 2011;22:588-595.
Bacchetti T, Vignini A, Giulietti A, Nanetti L, Provinciali L, Luzzi S, Mazzanti L, Ferretti G. Higher Levels of Oxidized Low Density Lipoproteins in Alzheimer's Disease Patients: Roles for Platelet Activating Factor Acetyl Hydrolase and Paraoxonase-1. J Alzheimers Dis. 2015;46(1):179-86.
Hong-Liang L, De-Pei L, Chihj-Chuan L. Paraoxonase gene polymorphisms, oxidative stress and diseases. J Mol Med. 2003;81:766-779.
Ściskalska M, Milnerowicz H. Importance of Polymorphisms in the Gene of Paraoxonase-1 (SNP rs662) and Apolipoprotein A-I (SNP rs670 and rs5069) in Non-Smoking and Smoking Healthy Subjects and Patients with Acute Pancreatitis. Genes (Basel). 2022;13(11):1968.
Dardiotis E, Aloizou AM, Siokas V, Tsouris Z, Rikos D, Marogianni C, Aschner M, Kovatsi L, Bogdanos DP, Tsatsakis A. Paraoxonase-1 genetic polymorphisms in organophosphate metabolism. Toxicology. 2019;411:24-31.
Delgado AJ, Ames PR, Donohue S, Stanyer L, Nourooz-Zadeh J, Ravirajan C, Isenberg DA. Antibodies to highdensity lipoprotein and beta2-glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome. Arthritis Rheum. 2003;48:284-296.
Kovacs TJ, Harris S, Vas TK, Seres I, Short CD, Wittmann IK, Paragh G, Mackness MI, Mackness B, Durrington PN, Nagy JM, Brenchley PEC. Paraoxonase gene polymorphism and serum activity in progressive IgA nephropathy. J Nephrol. 2006;19:732-738.
Hashemi MM, Mousavi E, Arab-Bafrani Z, Nezhadebrahimi A, Marjani A. The Most Effective Polymorphisms of paraoxonase-1 Gene on Enzyme Activity and Concentration of paraoxonase-1 Protein in Type 2 Diabetes Mellitus Patients and Non-Diabetic Individuals: A Systematic Review and Meta-Analysis. Diabetes Res Clin Pract..2019;152:135-145.
Agachan B, Yilmaz H, Ergen HA, Karaali ZE, Isbir T. Paraoxonase (PON1) 55 and 192 Polymorphism and Its Effects to Oxidant-Antioxidant System in Turkish Patients with Type 2 Diabetes Mellitus. Physiol Res. 2005;54:287-293.
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