Red Blood Cell Indices of Children with Varying Degrees of Malaria Parasitemia in Jos, Plateau State-Nigeria
Asian Hematology Research Journal,
Page 217-226
Abstract
Aim: This study aims to investigate the prevalence of haematological alterations and their diagnostic utility in malaria-infected children in Jos, Nigeria's Plateau state.
Study Design: This study is a cross-sectional study design to investigate the Red Blood Cell Indices of Children with Varying Degrees of Malaria Parasitemia in Jos, Plateau State-Nigeria.
Place and Duration of the Study: The study was conducted in Jos University Teaching Hospital. Data collection covered a specific duration between August, 2022 to January, 2023.
Methods: From August 2022 to January 2023, the study was conducted as a cross-sectional study at Jos University Teaching Hospital in Plateau State. A total of 384 MP positive cases were collected and used in the study, which included children who met the inclusion criteria and were diagnosed throughout the study period. All patients had full blood counts taken as well as different red blood cell indices.
Results: The Comparison between children with mild malaria parasitemia to those with low malaria parasitemia, there was a significant rise in the red blood cell count (P<.05). Children with low, moderate, and high parasitemia levels of malaria do not significantly differ in red blood cell count (P>.05). The results of this study also revealed that there is no difference between children with low, mild, moderate, and high parasitemia levels in terms of their hematocrit (P>.05). Furthermore, when compared to children with mild malaria parasitemia, the haemoglobin level in the high parasitemia group of kids was considerably lower (P<.05). The children with low, mild, moderate, and high malaria parasitemia did not exhibit any discernible change in mean corpuscular volume according to the study's findings (P>.05). Contrarily, the mean corpuscular haemoglobin concentration was significantly higher (P<.05) in the children with high malaria parasitemia than in the children with mild malaria parasitemia, and it was significantly higher (P<.05) in the children with moderate malaria parasitemia than in the children with mild malaria parasitemia. Comparing the RDW-CV in moderate malaria parasitemia to mild malaria parasitemia, there was a substantial reduction (P<.05) in both cases.
Conclusion: This study's main finding is that children with various densities of malarial parasites display significant disparities in the indices of red blood cells during the infection.
Keywords:
- Malaria
- red blood cell indices
- children
- Jos
How to Cite
References
World malaria report 2022 - World Health Organization - Google Books [Internet]. [cited 2023 Aug 3].
Available:https://books.google.com.ng/books?hl=en&lr=&id=ST-hEAAAQBAJ&oi=fnd&pg=PR6&ots=YYBTQaTiwg&sig=aXQbfwfZf239RnUYkU3sJXJVfOE&redir_esc=y#v=onepage&q&f=false
Hay SI, Okiro EA, Gething PW, Patil AP, Tatem AJ, Guerra CA, et al. Estimating the Global Clinical Burden of Plasmodium falciparum Malaria in 2007. PLoS Med. 2010;7(6):e1000290.
World Health Organization. World malaria report 2019 [Internet]. World Health Organization; 2019 [cited 2023 Aug 3]. Xxxix:185.
Available:https://apps.who.int/iris/handle/10665/330011
Staedke SG, Maiteki-Sebuguzi C, Rehman AM, Kigozi SP, Gonahasa S, Okiring J, et al. Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial): a cluster-randomised trial. Lancet Glob Health. 2018;6(6):e668–79.
Kotepui M, Phunphuech B, Phiwklam N, Chupeerach C, Duangmano S. Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border. Malar J. 2014;13(1): 218.
Adedapo AD, Falade CO, Kotila RT, Ademowo GO. Age as a risk factor for thrombocytopenia and anaemia in children treated for acute uncomplicated falciparum malaria. J Vector Borne Dis. 2007;44(4): 266–71.
Awoke N, Arota A. Profiles of hematological parameters in Plasmodium falciparum and Plasmodium vivax malaria patients attending Tercha General Hospital, Dawuro Zone, South Ethiopia. Infect Drug Resist. 2019;12:521–7.
Irwin JJ, Kirchner JT. Anemia in children. American Family Physician. 2001;64(8):1379-86.
Dondorp AM, Angus BJ, Chotivanich K, et al. Red blood cell deformability as a predictor of anemia in severe falciparum malaria. Am J Trop Med Hyg. 1999; 60(5):733-737.
DOI:10.4269/ajtmh.1999.60.733
Das BS, Nanda NK, Rath PK, Satapathy RN, Das DB. Anaemia in acute, Plasmodium falciparum malaria in children from Orissa state, India. Ann Trop Med Parasitol. 1999;93(2):109-118.
DOI:10.1080/00034989958591
Ekvall H. Malaria and anemia. Curr Opin Hematol. 2003;10(2):108-114.
DOI:10.1097/00062752-200303000-00002
Ajugwo, Anslem & Adias, Teddy. Red cell indices in nigerian malaria patients. Conference: 27th International conference of International Society for Laboratory Hematology (ISLH)At: Hague, Netherland; 2014
Kotepui M, Piwkham D, PhunPhuech B, Phiwklam N, Chupeerach C, Duangmano S. Effects of malaria parasite density on blood cell parameters. PLoS One. 2015; 10(3):e0121057.
Published 2015 Mar 25. DOI:10.1371/journal.pone.0121057
Haldar K, Mohandas N. Malaria, erythrocytic infection, and anemia. Hematology Am Soc Hematol Educ Program. 2009;87-93.
DOI:10.1182/asheducation-2009.1.87
Suwanarusk R, Cooke BM, Dondorp AM, et al. The deformability of red blood cells parasitized by Plasmodium falciparum and P. vivax. J Infect Dis. 2004;189(2):190-194.
DOI:10.1086/380468
Emmanuel AE, Adjekuko OC, Ahmadu BU, et al. Erythrocyte Indices and Leucocyte Count of Children with Plasmodium Falciparum Infection in Yola, Nigeria. Biomed J Sci & Tech Res. 2020;29 (3):213-217.
Available:https://doi.org/10.30574/wjarr.2020.7.3.0146.
-
Abstract View: 0 times
PDF Download: 0 times