Asian Hematology Research Journal

Biclonal B-Chronic Lymphocytic Leukemia: A rare Case Report with Review of Literature

Bansal Shashi

Department of Pathology- Haematopathology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India.

Syeda Firdos Jamil

Department of Pathology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India.

Talwar Amandeep

Department of Pathology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India.

Sharma Upendra

Department of Haemato-oncology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India.

*Author to whom correspondence should be addressed.

---

Abstract

Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia is a neoplasm composed of monomorphic small mature B cells that co-express CD5, CD23 and one type of immunoglobulin light chain either kappa or lambda, which  is necessary for the diagnosis. Here, we report a case in a 65 year woman with morphological diagnosis of B-Chronic Lymphocytic Leukemia. On flowcytometry analysis, immunoglobulin light chain restriction was not apparent as B cells expressed both kappa & lambda light chains without a clear monotypic population. Sequential gating on flowcytometry revealed two monoclonal B-cell populations and helped in identification of this rare case of biclonal disease in chronic lymphocytic leukemia (CLL).

Keywords: Lymphocytic, leukemia, B-cell, bone marrow

---

---